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Maternal Omega-6/Omega-3 Concentration Ratio During Pregnancy and Infant Neurodevelopment: The ECLIPSES Study.
Nutrients
January 2025
Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira i Virgili, 43201 Reus, Spain.
Background: The balance of omega-6/omega-3 (-6/-3) is crucial for proper brain function as they have opposite physiological roles.
Objectives: To analyze the association between maternal serum ratios of -6/-3 in the first and third trimesters of pregnancy and the neurodevelopment of their children in the early days after birth in the population of Northern Spain's Mediterranean region.
Methods: Longitudinal study in which 336 mother-child pairs participated.
Epigenetic Modulation with 5-Aza-CdR Prevents Metabolic-Associated Fatty Liver Disease Promoted by Maternal Overnutrition.
Nutrients
December 2024
Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Background/objectives: This study builds on previous findings from mouse models, which showed that maternal overnutrition induced by a high-fat diet (HFD) promotes metabolic-associated fatty liver disease (MAFLD) in offspring, linked to global DNA hypermethylation. We explored whether epigenetic modulation with 5-Aza-CdR, a DNA methylation inhibitor, could prevent MAFLD in offspring exposed to maternal overnutrition.
Methods: The offspring mice from dams of maternal overnutrition were fed either a chow diet or a high-fat diet (HFD) for 10 weeks.
Comparative Impact of Alternate-Day Fasting and Time-Restricted Feeding on Placental Function and Fetal Development in Maternal Obesity.
Nutrients
December 2024
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Background: Maternal obesity detrimentally affects placental function and fetal development. Both alternate-day fasting (ADF) and time-restricted feeding (TRF) are dietary interventions that can improve metabolic health, yet their comparative effects on placental function and fetal development remain unexplored.
Objectives: This study aims to investigate the effects of ADF and TRF on placental function and fetal development during maternal consumption of a high-fat diet (HFD).
Development and validation of a nomogram-based prognostic model to predict coronary artery lesions in Kawasaki disease from 6847 children in China.
Comput Methods Programs Biomed
January 2025
Department of Cardiology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China. Electronic address:
Background And Objective: Predicting potential risk factors for the occurrence of coronary artery lesions (CAL) in children with Kawasaki disease (KD) is critical for subsequent treatment. The aim of our study was to establish and validate a nomograph-based model for identifying children with KD at risk for CAL.
Methods: Hospitalized children with KD attending Wuhan Children's Hospital from Jan 2011 to Dec 2023 were included in the study and were grouped into a training set (4793 cases) and a validation set (2054 cases) using a simple random sampling method in a 7:3 ratio.
Maternal autoimmune systemic connective tissue disease and vasculitis and electrocardiographic findings in the offspring.
J Autoimmun
January 2025
Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Cardiology, Copenhagen University Hospital, Herlev-Gentofte Hospital, Copenhagen, Denmark.
Introduction: Maternal autoimmune systemic connective tissue diseases (CTDs) and their related antibodies have been associated with adverse fetal outcomes, including complete heart block. In this study, we assessed the association between maternal CTD or vasculitis and neonatal electrocardiographic (ECG) parameters.
Methods: Our study population was drawn from the Copenhagen Baby Heart Study (CBHS), a prospective, population-based cohort study open to all neonates born in the Copenhagen area.
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