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A clinical case of a man 66 y.o. who was diagnosed with hormone-inactive pituitary macroadenoma complicated by corneal erosion and partial atrophy of the optic nerve of the left eye due to exophthalmos.
View Article and Find Full Text PDFCushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21.
J Allergy Clin Immunol
January 2022
Immunology Service, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health (NIH), Bethesda, Md. Electronic address:
Article Synopsis
- Pediatric endogenous Cushing syndrome (eCs) is caused by pituitary tumors that produce corticotropin, leading to symptoms similar to long-term glucocorticoid therapy, which allows researchers to study its effects on immunity.
- The study involved immunologic analyses of healthy pediatric eCs patients before and after tumor removal, using various advanced techniques to investigate T-cell function and responses.
- Findings revealed that eCs patients had decreased thymic output and T-cell levels, alongside increased apoptosis, but these issues normalized post-surgery; additionally, the introduction of IL-21 showed potential in mitigating the adverse effects of glucocorticoids on T-cells.
Localization of ectopic corticotropin-producing carcinoid tumor with use of indium-111 pentetreotide scintigraphy.
Endocr Pract
February 2005
Division of General Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.
Objective: To report on the diagnosis of ectopic corticotropin (adrenocorticotropic hormone [ACTH])-producing bronchial carcinoid tumor by indium-111 pentetreotide (octreotide scan) scintigraphy.
Methods: We present a case of ectopic ACTH syndrome caused by an occult bronchial carcinoid tumor arising in a lymph node and review the pertinent literature.
Results: Biochemical diagnosis of ACTH syndrome can be difficult, and conventional imaging modalities often do not demonstrate these small carcinoid tumors.
Lymphocytic hypophysitis in a man presenting with hypercalcemia.
Am J Med Sci
March 2001
Department of Pathology, Harbor-UCLA Medical Center, Los Angeles, California, USA.
A 59-year-old man with a 30-year history of type 2 diabetes mellitus presented with fatigue, confusion, and weight loss over a 3-month period. He was found to be hypercalcemic (11.8 mg/dL) and dehydrated, and his hypercalcemia improved with intravenous fluids.
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