AI Article Synopsis
- The study aimed to evaluate whether radiosurgery for benign tumors poses a risk of turning them malignant or causing new cancers.
- It involved a review of data from around 5000 patients in Sheffield, comparing their outcomes with national cancer statistics over a follow-up period that included more than 1200 patients for over a decade.
- The findings indicated no significant increase in cancer risk, supporting radiosurgery's safety, especially when considering the other risks that patients with brain tumors face.
Article Abstract
Objective: To assess the risk of radiosurgery to cause malignant transformation in benign tumors or to induce new malignancies.
Methods: A retrospective cohort study comparing the Sheffield, England, radiosurgery patient database with national mortality and cancer registries. This data set comprises approximately 5000 patients and 30,000 patient-years of follow-up, with more than 1200 patients having a follow-up period longer than 10 years.
Results: In this material, a single new astrocytoma was diagnosed, whereas, based on national incidence figures, 2.47 cases would have been predicted.
Conclusion: No increased risk of malignancy was detected in this series, supporting the safety of radiosurgery. Pragmatically, in advising patients, the risks of malignancy would seem small, particularly if such risks are considered in the context of the other risks faced by patients with intracranial pathologies requiring radiosurgical treatments.
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| http://dx.doi.org/10.1227/01.NEU.0000255492.34063.32 | DOI Listing |
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