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The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis.
Org Biomol Chem
August 2012
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
The spirastrellolides are a novel family of structurally unprecedented marine macrolides which show promising anticancer properties due to their potent inhibition of protein phosphatase 2A. In the preceding paper, a modular strategy for the synthesis of spirastellolide A methyl ester which allowed for the initial stereochemical uncertainties was outlined, together with the synthesis of a series of suitably functionalised fragments. In this paper, the realisation of this synthesis is described.
View Article and Find Full Text PDFSpirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core.
J Am Chem Soc
January 2007
Department of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, BC, Canada.
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