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Raman Imaging of Targeted Drug Delivery with DNA-Based Nano-Optical Devices.
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December 2024
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Raman spectroscopy (RS) has emerged as a novel optical imaging modality by identifying molecular species through their bond vibrations, offering high specificity and sensitivity in molecule detection. However, its application in intracellular molecular probing has been limited due to challenges in combining vibrational tags with functional probes. DNA nanostructures, known for their high programmability, have been instrumental in fields like biomedicine and nanofabrication.
View Article and Find Full Text PDFMMP2 enzyme-responsive extracellular vesicles as dual-targeted carriers to promote the phagocytosis of macrophages.
Colloids Surf B Biointerfaces
February 2025
State Key Laboratory of Molecular Oncology, National Cancer Center, China; National Clinical Research Center for Cancer, China; Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Combination therapy using inhibition of tumor cell escape and alteration of the tumor microenvironment offers a new strategy for cancer treatment. This study aimed to develop an extracellular vesicle (EV) carrier that regulates tumor cells and the tumor microenvironment to achieve efficient tumor immunotherapy. The ligand modified on carriers targets the immune checkpoint CD47 protein, blocking tumor cell escape.
View Article and Find Full Text PDFEnzyme-Responsive DNA Condensates.
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Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy.
Membrane-less compartments and organelles are widely acknowledged for their role in regulating cellular processes, and there is an urgent need to harness their full potential as both structural and functional elements of synthetic cells. Despite rapid progress, synthetically recapitulating the nonequilibrium, spatially distributed responses of natural membrane-less organelles remains elusive. Here, we demonstrate that the activity of nucleic-acid cleaving enzymes can be localized within DNA-based membrane-less compartments by sequestering the respective DNA or RNA substrates.
View Article and Find Full Text PDFHydrophobicity as a tool for programming sequential mesophase transitions of enzyme-responsive polymeric amphiphiles.
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November 2024
Department of Organic Chemistry, School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Article Synopsis
- The study explores how to control the transition rates in enzyme-responsive polymeric micelles by adjusting the hydrophobic properties of their components.
- Researchers used different types of amphiphilic molecules that respond to enzymes to create a sequence of changes, from micelles to hydrogels and then into dissolved polymers.
- The findings highlight the critical role of molecular design and hydrophobicity in developing programmable polymer systems, enabling precise control over their behavior for specific applications.
Charge-Reversal Nano-Drug Delivery Systems in the Tumor Microenvironment: Mechanisms, Challenges, and Therapeutic Applications.
Int J Mol Sci
September 2024
Department of Biochemistry & Molecular Biology, School of Life Sciences, China Medical University, Shenyang 110122, China.
The charge-reversal nano-drug delivery system (CRNDDS) is a promising system for delivering chemotherapy drugs and has gained widespread application in cancer treatment. In this review, we summarize the recent advancements in CRNDDSs in terms of cancer treatment. We also delve into the charge-reversal mechanism of the CRNDDSs, focusing on the acid-responsive, redox-responsive, and enzyme-responsive mechanisms.
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