The effects of acitretin and etretinate on angiogenesis induced in Balb/c mice by intradermal injection of keratinocyte tumor cell lines were evaluated. It was shown that both retinoids are capable of inhibiting angiogenesis evoked by a human epidermoid carcinoma cell line (A431). Acitretin, but not etretinate, inhibited also angiogenesis induced by the spontaneously transformed murine keratinocyte cell line Pam 212 and by the established tumorigenic SKv cell line harboring the HPV16 genome. We suggest that inhibition of blood vessel formation may be one of the mechanisms responsible for the anticancerogenic effect of retinoids.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000210941 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combined Abrocitinib and Acitretin Therapy for Darier's Disease: A Case Report.
Clin Cosmet Investig Dermatol
December 2024
Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong, 510095, People's Republic of China.
Darier's disease (DD) is a rare chronic keratinizing skin disease characterized by dyskeratosis of epidermal cells. We report a case of DD with a medical history spanning over 20 years and recurring symptoms. Pathologically confirmed DD was treated with a combination of abrocitinib and acitretin, resulting in rapid symptom resolution within 2 weeks.
View Article and Find Full Text PDFAntibiotic, hormonal/metabolic, and retinoid therapies for hidradenitis suppurativa.
J Am Acad Dermatol
December 2024
Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:
Background: Hidradenitis suppurativa (HS), a chronic painful inflammatory skin condition, remains a persistent challenge in dermatology. Its complex pathogenesis has yet to be fully understood, complicating the identification of effective therapeutic strategies.
Objective: This study aims to investigate the latest insights on antibiotics, hormonal/metabolic interventions, and oral retinoids in the management of HS.
Acrodermatitis continua of hallopeau: aggravating factors and treatment outcomes of 96 patients.
J Dermatolog Treat
December 2024
Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant predominantly affects the distal phalanges of the fingers and toes. However, data on aggravating factors and treatment outcomes is limited.
Objective: This study aims to analyze the aggravating factors and treatment outcomes of ACH in a three-tertiary-hospital in South China.
Update on skin cancer prevention modalities and screening protocols in solid organ transplant recipients: a scoping review.
Arch Dermatol Res
November 2024
Department of Dermatology, Kaiser Permanente, Roseville, CA, USA.
Article Synopsis
- Solid organ transplant recipients (SOTRs) face a significantly higher risk of skin cancer due to long-term use of immunosuppressants, but there are no standardized screening guidelines in the U.S. for this population.
- A scoping review analyzed 36 studies published from 2019 to 2023, focusing on skin cancer risk stratification, screening protocols, and preventive treatments for SOTRs, revealing that most studies emphasize screening and chemoprevention.
- The SUNTRAC tool was identified as a validated model for assessing skin cancer risk, with various preventive strategies suggested, and the review calls for standardized guidelines and more research on patient education and the tool's validation in diverse groups.
Successful treatment of refractory palmoplantar pustulosis by upadacitinib: report of 28 patients.
Front Med (Lausanne)
November 2024
Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Background: Upadacitinib, a specific JAK1 inhibitor, has minimal effect on other JAK subtypes. It influences the inflammatory process in various ways. Upadacitinib has been approved for conditions such as rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, and ulcerative colitis in various countries.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!