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Association of Cytotoxic T-Lymphocyte Antigen-4 () Genetic Variants with Risk and Outcome of Cutaneous Melanoma.
Int J Mol Sci
November 2024
Laboratory of Cancer Genetics, School of Medical Sciences, State University of Campinas, Campinas 13083-970, SP, Brazil.
This study aimed to verify whether germline single nucleotide variants (SNV) in gene, c.-1765C>T, c.-1661A>G, c.
View Article and Find Full Text PDFAssociation of CTLA-4 polymorphisms with hematologic malignancy susceptibility: a meta-analysis.
Front Oncol
October 2024
Department of Hematology, the Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
Background: Recent studies have reported an association between Cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphisms and hematologic malignancy susceptibility, while the results remain inconsistent. Hence, we performed a meta-analysis to investigate the association between CTLA-4 polymorphisms with hematologic malignancy susceptibility.
Methods: A comprehensive and systematic search of Cochrane Library, PubMed, Embase databases was performed up to Sep.
[Association of CTLA-4 gene polymorphisms with the genetic susceptibility and prognosis of patients with Bladder urothelial carcinoma].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2024
Department of Urology, Xinxiang Central Hospital, Xinxiang, Henan 453000, China.
Objective: To assess the association of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms with the prognosis of patients with Bladder urothelial carcinoma (BUC).
Methods: From February 2019 to October 2020, 256 BUS patients treated at the Xinxiang Central Hospital were selected as the study group, whilst 250 healthy individuals were selected as the control group. Genotypes of rs5742909 (-318C/T), rs231775 (+49A/G) and rs4553808 (-1661A/G) were determined by PCR-restriction fragment length polymorphism assay.
Effects of CTLA-4 Single Nucleotide Polymorphisms on Toxicity of Ipilimumab-Containing Regimens in Patients With Advanced Stage Melanoma.
J Immunother
June 2024
Department of Medical Oncology, Cantonal Hospital Muensterlingen, Muensterlingen, Switzerland.
Single nucleotide polymorphisms (SNPs) in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene, an inhibitor of T-cell priming, are associated with auto and alloimmunity. Studies implied a role for these SNPs as surrogate markers for immunotherapy-outcome in patients with melanoma. However, no predictive SNPs are defined to date.
View Article and Find Full Text PDFCTLA-4 polymorphisms in Thai patients with rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis.
Int J Rheum Dis
November 2021
School of Pharmacological Sciences, University of Shizuoka, Shizuoka, Japan.
Aims: Studies on polymorphisms of the cytotoxic T lymphocytes associated antigen-4 (CTLA-4) genes in rheumatic disease patients are limited in Southeast Asia. This pilot study aimed to determine CTLA-4 polymorphisms in Thai patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), and correlate them with serology.
Method: One-hundred RA, 70 SLE and 50 SSc patients, and 99 healthy controls (HCs) were included in this study.
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