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Adherence, Fears, and Beliefs about Biologic Drugs in Rheumatoid Arthritis Patients: A North African Pilot Study.
Mediterr J Rheumatol
December 2024
University of Sousse, Faculty of Medicine of Sousse, Farhat Hached Hospital, Sousse, Research Laboratory "Heart Failure, LR12SP09", Sousse, Tunisia.
Purpose: To investigate the impact of beliefs in adherence to biologic drugs among patients with rheumatoid arthritis (RA).
Methods: This was a cross-sectional study, including RA patients who were on biologic disease-modifying antirheumatic drugs (bDMARDs). Therapeutic adherence was evaluated arbitrarily using a self-reported method by asking them the following question: "Do you regul arly take your biologic drug as prescribed by your doctor?".
Impact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses.
Front Pharmacol
January 2025
Certara Inc., Melbourne, VIC, Australia.
Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression analyses with binary endpoints, several exposure metrics are investigated, based on pharmacological plausibility, including time-averaged concentration to event (C). C is informative because it accounts for dose interruptions, modifications, and reductions and is therefore often compared against ER relationships identified using steady-state exposures.
View Article and Find Full Text PDFSeparation of 100 nm-sized nanoparticles using a poly-Lys-modified monolith column.
RSC Adv
January 2025
Center of Electron Microscopy, Showa University Japan.
Nanoparticles (approximately 100 nm in diameter) composed of lipid layers containing drugs or biologically active substances are attracting increasing attention in various fields, including medicine, as well as for signal transduction between cells. However, the separation of such nanoparticles conventional HPLC is challenging, often resulting in the clogging and collapse of nanoparticles, as well as a low separation efficiency. Thus far, no HPLC column capable of efficiently separating two types of 100 nm-sized nanoparticles in a short time has been reported.
View Article and Find Full Text PDFThe antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.
BMC Oral Health
January 2025
Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.
Background: To investigate the antibiofilm effect and mechanism of the silver nanowire (AgNW)-modified glass ionomer cement (GIC) against multi-species oral biofilm, and to examine the mechanical and biochemical properties of this novel GIC material.
Methods: Conventional GIC was incorporated with different concentrations of AgNW and silver nanoparticles (AgNP). Multi-species biofilms of Streptococcus mutans, Streptococcus sobrinus, Lactobacillus fermentum, and Lactobacillus rhamnosus were cultured for 72 h on GIC specimens.
Biomarker analysis from complex biofluids by an on-chip chemically modified light-controlled vertical nanopillar array device.
Nat Protoc
January 2025
Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv-Yafo, Israel.
Nanostructured devices have proven useful in a broad range of applications, from diagnosing diseases to discovering and screening new drug molecules. We developed vertical silicon nanopillar (SiNP) arrays for on-chip multiplex capture of selected biomolecules using a light-induced release of the array's selectively captured biomarkers. This platform allows the rapid, reusable and quantitative capture and release of a selection of biomarkers, followed by their downstream analysis.
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