[Study on bile excretion of scutellarein].
Zhongguo Zhong Yao Za Zhi
School of Pharmaceutical Sciences, Beijing University, Beijing 100083, China.
Published: October 2006
Objective: A HPLC-ECD method was established to determine scutellarin in rat bile.
Method: The analytical column was Prontosil C18 (4.6 mm x 250 mm, 5 microm), and the mobile phase was consisted of methanol, 50 mmol x L(-1) phosphate buffer (adjusted by phosphoric acid to pH 2. 6), and tetrahydrofuran (40: 60: 10) , the flow rate was 1.0 mL x min(-1); the potential electrode voltage was 100 mv.
Result: Concentration profile of scutellarin in rat bile was shown in this paper after oral administration of scutellarein.
Conclusion: Only scutellarin was detected in rat bile, while both of scutellarin and scutellarein were detected in rat plasma.
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