AI Article Synopsis
- Researchers discovered eleven new G-protein coupled receptor sequences in the amphioxus species Branchiostoma floridae, named AmphiAmR1-11.
- These receptors exhibit structural similarities to both vertebrate and invertebrate aminergic GPCRs and involve a preliminary classification using advanced analytical techniques.
- The amphioxus genome shows expression of various receptors, including those related to dopamine, octopamine, alpha-adrenergic, and histamine, with several identified in cDNA libraries from different tissues.
Article Abstract
We have identified eleven novel aminergic-like G-protein coupled receptor (GPCRs) sequences (named AmphiAmR1-11) by searching the genomic trace sequence database for the amphioxus species, Branchiostoma floridae. They share many of the structural motifs that have been used to characterize vertebrate and invertebrate aminergic GPCRs. A preliminary classification of these receptors has been carried out using both BLAST and Hidden Markov Model analyses. The amphioxus genome appears to express a number of D1-like dopamine receptor sequences, including one related to insect dopamine receptors. It also expresses a number of receptors that resemble invertebrate octopamine/tyramine receptors and others that resemble vertebrate alpha-adrenergic receptors. Amphioxus also expresses receptors that resemble vertebrate histamine receptors. Several of the novel receptor sequences have been identified in amphioxus cDNA libraries from a number of tissues.
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| http://dx.doi.org/10.1007/s10158-006-0041-z | DOI Listing |
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