AI Article Synopsis
- The study compared the effectiveness and immune response of the MMR vaccine given alone versus in combination with the varicella vaccine (MMR and V) in infants.
- It included a group that received the MMR vaccine 42 days later to observe any impact on immune development.
- Results showed similar antibody production and immune responses across groups, with no significant differences or unintended immune effects detected from the vaccines.
Article Abstract
This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella (MMR and V). In an additional group, MMR vaccination was delayed 42 days to permit analysis of potential effects on underlying maturation of systemic immune functions. Assessment of immunity to the vaccines indicated consistent antibody production coupled with mixed Th1/Th2 memory, and no significant differences between vaccine groups or to the group who had their MMR vaccination delayed. Parallel analyses of cytokine responses to phytohaemagglutinin and tetanus toxoid did not detect any "bystander" effects of the vaccines on systemic immunity.
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| http://dx.doi.org/10.1016/j.vaccine.2006.11.022 | DOI Listing |
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