Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding.

Chem Commun (Camb)

Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.

Published: January 2007

The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913474PMC
http://dx.doi.org/10.1039/b614557dDOI Listing

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