Studies on acyclic pyrimidines as inhibitors of mycobacteria.

Bioorg Med Chem

Department of Laboratory Medicine and Pathology, 1-41 Medical Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2H7.

Published: March 2007

In vitro anti-mycobacterial activities of several 5-substituted acyclic pyrimidine nucleosides containing 1-(2-hydroxyethoxy)methyl and 1-[(2-hydroxy-1-(hydroxymethyl) ethoxy)methyl] acyclic moieties are investigated against three mycobacteria viz. Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium, which cause serious infections and mortality in healthy people as well as patients with AIDS. 1-(2-Hydroxyethoxy)methyl-5-(1-azido-2-haloethyl or 1-azidovinyl) analogs (4-7), 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-5-decynyluracil (37), and 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-5-dodecynyluracil (38) exhibited significant in vitro anti-tubercular activity against these mycobacteria.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2006.12.032DOI Listing

Publication Analysis

Top Keywords

studies acyclic
4
acyclic pyrimidines
4
pyrimidines inhibitors
4
inhibitors mycobacteria
4
mycobacteria vitro
4
vitro anti-mycobacterial
4
anti-mycobacterial activities
4
activities 5-substituted
4
5-substituted acyclic
4
acyclic pyrimidine
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!