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Syndromic Association of Depigmentation With Congenital Hearing Loss: A Review of Three Children With Auditory Pigmentary Disorders.
Ear Nose Throat J
December 2024
Department of Otorhinolaryngology and Head-Neck Surgery, Medical College and Hospital, Kolkata, West Bengal, India.
Congenital depigmentation may be associated with congenital sensorineural hearing loss leading to non-development of verbal speech. To illustrate the clinical features and work-up of 3 children diagnosed with auditory pigmentary disorders (APDs). Case series with a review of the literature.
View Article and Find Full Text PDFMorphometry of choroid plexus epithelial cells in neurodegenerative diseases.
Neuropathology
November 2024
Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, Japan.
Article Synopsis
- The choroid plexus plays a vital role in producing cerebrospinal fluid and regulating circadian rhythms, which can be affected by neurodegenerative diseases like Alzheimer's.
- A study analyzed brain samples from patients with Alzheimer's, vascular dementia, Parkinson's disease, and multiple system atrophy, focusing on the morphology of choroid plexus epithelial cells.
- Results showed no significant changes in epithelial cell measurements across the different disease groups, but age was positively correlated with cell size, suggesting that aging affects these cells regardless of neurodegenerative conditions.
Microphthalmia with multiple ocular abnormalities in a foal.
Vet Ophthalmol
July 2024
Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA.
Article Synopsis
- The report details the clinical examination and imaging findings of a 12-hour-old foal with microphthalmia and various eye abnormalities, including blindness and strabismus.
- Diagnostic techniques employed included a thorough ophthalmic examination, ultrasound biomicroscopy, and histopathology to assess the condition of the eyes.
- Findings revealed that the foal's eyes were significantly underdeveloped with no lenses, disorganized tissue, and signs of retinal detachment and dysplasia, highlighting the rarity of this congenital condition.
Use of recombinant tissue plasminogen activator (rTPA) for treatment of fibrin in the anterior chamber of the horse.
Vet Med Sci
July 2024
Pool House Equine Hospital, IVC Evidensia, Malton, UK.
Background: Recombinant intracameral tissue plasminogen activator (rTPA) administration can aid clearance of fibrin from the anterior chamber.
Materials And Methods: In this retrospective multicentre case series, the effect of intracameral rTPA administration to treat fibrin in the anterior chamber resulting from trauma or inflammatory ocular disease was evaluated. Clinical data from 30 treatments in 29 horses were obtained from medical records from 2003 to 2022.
Extensive intraocular melanoma with secondary glaucoma in a 15-month-old Thoroughbred filly.
Vet Med Sci
May 2024
Department of Rossdales Laboratories, Rossdales Equine Hospital and Diagnositc Centre, Newmarket, UK.
Article Synopsis
- A 15-month-old Thoroughbred filly was diagnosed with glaucoma in the right eye, which was linked to a mass in the anterior chamber causing corneal edema and blepharospasm.
- Following treatment for the secondary glaucoma, the mass was identified as a likely intraocular melanoma, leading to an enucleation procedure.
- Histopathological analysis confirmed it as a unique case of invasive uveal melanoma, highlighting the importance of considering this diagnosis in glaucoma cases in young horses.
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