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[Patterns of CAF expression in tumors of the genitourinary system].
Arkh Patol
December 2024
Lomonosov Moscow State University, Moscow, Russia.
Article Synopsis
- - The study focuses on cancer-associated fibroblasts (CAF) in tumors, particularly looking at the markers FAP and PDGFR in bladder and prostate cancers, noting the complexity and variation of CAF functions in tumor development.
- - Researchers analyzed tissue samples from 34 prostate cancer patients and 44 bladder cancer patients to identify the relationship between CAF markers and cancer characteristics like stage, morphology, and survival.
- - Findings show that FAP is linked to metastasis and recurrence in prostate cancer, while its presence is exclusive to invasive bladder cancers, highlighting FAP's potential as a significant marker for diagnosing and understanding treatment resistance in genitourinary tumors.
Integrated Transcriptome Profiling and Pan-Cancer Analyses Reveal Oncogenic Networks and Tumor-Immune Modulatory Roles for FABP7 in Brain Cancers.
Int J Mol Sci
November 2024
Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
Fatty acid binding protein 7 (FABP7) is a multifunctional chaperone involved in lipid metabolism and signaling. It is primarily expressed in astrocytes and neural stem cells (NSCs), as well as their derived malignant glioma cells within the central nervous system. Despite growing evidence for FABP7's tumor-intrinsic onco-metabolic functions, its mechanistic role in regulating the brain tumor immune microenvironment (TIME) and its impact on prognosis at the molecular level remain incompletely understood.
View Article and Find Full Text PDFUndifferentiated embryonal sarcoma of the liver masquerading as a cystadenoma in a young adult: a case report.
J Med Case Rep
November 2024
Department of Radiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, China.
Article Synopsis
- Undifferentiated embryonal sarcoma of the liver is a rare cancer mostly affecting children, and is even less common in adults; proper imaging is crucial to avoid misdiagnosing it with more common liver masses.
- A 37-year-old Chinese woman presented with abdominal pain and underwent multiple imaging tests revealing a cystic-solid liver nodule, initially thought to be benign.
- The definitive indication of malignancy came from a PET-CT scan, which showed abnormal F-fluorodeoxyglucose uptake, prompting the correct diagnosis of undifferentiated embryonal sarcoma of the liver.
Comprehensive Genomic Assessment of Advanced-Stage GI Stromal Tumors Using the Japanese National Center for Cancer Genomics and Advanced Therapeutics Database.
JCO Precis Oncol
October 2024
Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Purpose: Clinical utility of comprehensive genomic profiling (CGP) for precision medicine has become evident. Although there are several reports on the genomic landscape of GI stromal tumors (GISTs), large-scale data specific to GIST are limited, especially in Asia. Additionally, the applicability of molecular-targeted agents identified using CGP has not been extensively examined.
View Article and Find Full Text PDFMolecular profiling of oral epithelial dysplasia and oral squamous cell carcinoma using next generation sequencing.
J Stomatol Oral Maxillofac Surg
October 2024
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Background: Next generation sequencing (NGS) is a massive, high-throughput sequencing technology used to analyze various mutations and genetic changes in cancer. Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck region. OSCC usually arises from oral potentially malignant disorders, like oral leukoplakia, oral submucous fibrosis and erythroplakia, and shows mutation of tumor suppressor genes, and several other critical genes involved in apoptotic pathways, cell migration, and cell growth.
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