AI Article Synopsis
- - The study investigates the risk of end-stage liver disease (ESLD) in hemophilia patients infected with hepatitis C virus (HCV) between 1961 and 1990, tracking outcomes until August 2005.
- - Out of 847 patients, 19% cleared the virus spontaneously while 81% developed chronic HCV; the cumulative incidence of ESLD was significantly higher in HIV-positive patients (35.1% vs 11.5% in HIV-negative).
- - Key risk factors for developing ESLD included HIV coinfection, older age at infection, alcohol abuse, and having HCV genotype 1, highlighting the increasing risk with longer HCV infection duration.
Article Abstract
Prior to 1990, many patients with inherited bleeding disorders were infected with hepatitis C virus (HCV). This study assessed the risk of end-stage liver disease (ESLD) in patients with hemophilia with chronic hepatitis C. Patients were infected between 1961 and 1990 and were followed up to August 2005. Of 847 anti-HCV(+) patients, 160 (19%) spontaneously cleared HCV and 687 (81%) developed chronic hepatitis C. Coinfection with HIV was present in 210 patients. After 35 years of infection the cumulative incidence of ESLD was 11.5% (95% CI, 8.2%-14.8%) in HIV(-) patients and 35.1% (95% CI, 29.2%-41.0%; P < .001) in patients coinfected with HIV. Independent risk factors of ESLD were HIV coinfection (hazard ratio 13.8; 95% CI, 7.5-25.3), older age at infection (hazard ratio 2.3 per 10 years; 95% CI, 2.0-2.8), alcohol abuse (hazard ratio 4.9; 95% CI, 2.5-9.6), and presence of HCV genotype 1 (hazard ratio 2.2; 95% CI, 1.1-4.2). With longer duration of HCV infection, the risk of developing ESLD is emerging in patients with inherited bleeding disorders. Risk factors for rapid progression to ESLD are alcohol abuse, coinfection with HIV, older age at infection, and presence of HCV genotype 1.
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| http://dx.doi.org/10.1182/blood-2006-08-038349 | DOI Listing |
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