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Molecular Mechanisms Underlying the Loop-Closing Dynamics of β-1,4 Galactosyltransferase 1.
J Chem Inf Model
December 2024
Xuzhou College of Industrial Technology, Xuzhou 221140, Jiangsu Province, China.
The β-1,4 galactosylation catalyzed by β-1,4 galactosyltransferases (β4Gal-Ts) is not only closely associated with diverse physiological and pathological processes in humans but also widely applied in the -glycan modification of protein glycoengineering. The loop-closing process of β4Gal-Ts is an essential intermediate step intervening in the binding events of donor substrate (UDP-Gal/Mn) and acceptor substrate during its catalytic cycle, with a significant impact on the galactosylation activities. However, the molecular mechanisms in regulating loop-closing dynamics are not entirely clear.
View Article and Find Full Text PDFα-FeO and polypyrrole impregnated alginate/gelatin nanocatalysts for the reduction of azo dyes and persistent organic pollutants.
Int J Biol Macromol
December 2024
Materials Polymer Laboratory, Macromolecular Chemistry Department, Faculty of Chemistry, University of Sciences and Technology Houari Boumediene USTHB, B.P. 32 El-Alia, 16111 Algiers, Algeria.
Herein, we propose magnetic nanocomposites as a powerful new catalyst for organic pollutant reduction. Polypyrrole (PPy) was synthesized in situ within the semi-interpenetrating alginate (Alg)/gelatin (Ge) network in presence of α-FeO as encapsulating matrix and inorganic filler, respectively. The polymeric matrix can act as bifunctional agent such as a binder and stabilizer to improve nanocatalyst stability while preserving their catalytic/magnetic performances.
View Article and Find Full Text PDFRevolutionizing nanozymes: The synthesis, enzyme-mimicking capabilities of carbon dots, and advancements in catalytic mechanisms.
Int J Biol Macromol
December 2024
Shengli Clinical Medical College of Fuzhou Medical University, Department of Pediatric Surgery, Fuzhou, Fujian 350001, China. Electronic address:
Nanozymes, a revolutionary category of engineered artificial enzymes based on nanomaterials, have been developed to overcome the inherent limitations of natural enzymes, such as the high cost associated with storage and their fragility. Carbon dots (CDs) have emerged as compelling candidates for various applications due to their versatile properties. Particularly noteworthy are CDs with a range of surface functional groups that exhibit enzyme-like behavior, combining exceptional performance with catalytic capabilities.
View Article and Find Full Text PDFDirected evolution of glutamate decarboxylase B for enhancing its enzyme activity towards nearly neutral pHs based on error-prone PCR.
Int J Biol Macromol
December 2024
College of Food Science and Biotechnology, Zhejiang Gongshang University, 149 Jiaogong Road, Hangzhou, Zhejiang Province 310035, People's Republic of China. Electronic address:
Glutamate decarboxylases (GADs) can catalyze the conversion of l-glutamate to γ-aminobutyric acid (GABA), while consuming one H. However, the GADs found so far are catalytically active in the pHs of 3.8-5.
View Article and Find Full Text PDFDeveloping photoactivated artificial enzymes for sustainable fuel production.
Curr Opin Chem Biol
December 2024
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA. Electronic address:
Enzymes catalyze molecular reactions with remarkable efficiency and selectivity under mild conditions. Photoactivated enzymes make use of a light-absorbing chromophore to drive chemical transformations, ideally using sunlight as an energy source. The direct attachment of a chromophore to native enzymes is advantageous, as information on the underlying catalytic mechanisms can be obtained.
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