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Proteomic Profiling of Extracellular Vesicles in Inflammatory Bowel Diseases.
Int J Mol Sci
January 2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
The proteomic analysis of serum extracellular vesicles (EVs) could be a useful tool for studying the pathophysiology of Crohn's disease (CD) and ulcerative colitis (UC), as well as for biomarker discovery. To characterize the proteomic composition of serum EVs in patients with CD and UC to identify biomarkers and molecular pathways associated with pathogenesis and activity. Methods: Serum EVs were enriched and analyzed in patients with quiescent CD, active CD (aCD), quiescent UC, active UC (aUC), and healthy controls (HCs) (n = 30 per group).
View Article and Find Full Text PDFExtended quantum anomalous Hall states in graphene/hBN moiré superlattices.
Nature
January 2025
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Electrons in topological flat bands can form new topological states driven by correlation effects. The pentalayer rhombohedral graphene/hexagonal boron nitride (hBN) moiré superlattice was shown to host fractional quantum anomalous Hall effect (FQAHE) at approximately 400 mK (ref. ), triggering discussions around the underlying mechanism and role of moiré effects.
View Article and Find Full Text PDFMental Health Issues Associated With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
J Clin Endocrinol Metab
January 2025
Department of Pediatrics, Susan B. Meister Child Health Evaluation and Research (CHEAR) Center, Michigan Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Context: The goal of this review is to move beyond summarizing what is known about psychosexual development in females with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency-commonly studied as a natural experiment to understand prenatal androgen effects in 46,XX individuals. Instead, it will explore the various aspects of the condition that significantly impact the daily lives of both male and female patients and their families, with a particular focus on the implications for psychosocial, educational, and vocational adaptation.
Evidence Acquisition: This work represents a selective, yet balanced review of papers highlighting potential threats to positive psychological adaptation in both male and female individuals with CAH.
Unprecedented Site Preference of Sn in the Structure of CoSn-Type NiInSn ( < 0.7).
Inorg Chem
January 2025
Department of Chemistry, IIT Kharagpur, Kharagpur 721302, India.
A series of compositions NiInSn ( = 0-1) were synthesized by conventional high-temperature synthesis, and as-synthesized samples were checked by powder X-ray diffraction experiments. NiInSn ( < 0.7) mainly forms the ternary variant of the CoSn-type structure (6/), whereas, = 0.
View Article and Find Full Text PDFLongitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus.
Lupus Sci Med
January 2025
Rheumatology Research Group, Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
Objective: To estimate the prevalence of organ damage (damage) and flare and to examine longitudinal associations between flares and subsequent damage accrual, in patients with systemic lupus erythematosus (SLE).
Methods: Patients enrolled in the Asia Pacific Lupus Collaboration cohort with ≥3 years of prospectively captured data were studied. Flares were assessed at routine visits, while damage ((Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index) was assessed annually.
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