Zinc-fingers (ZnFs) are extremely abundant in higher eukaryotes. Once considered to function exclusively as sequence-specific DNA-binding motifs, ZnFs are now known to have additional activities such as the recognition of RNA and other proteins. Here we discuss recent advances in our understanding of ZnFs as specific modules for protein recognition. Structural studies of ZnF complexes reveal considerable diversity in terms of protein partners, binding modes and affinities, and highlight the often underestimated versatility of ZnF structure and function. An appreciation of the structural features of ZnF-protein interactions will contribute to our ability to engineer and to use ZnFs with tailored protein-binding properties.
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http://dx.doi.org/10.1016/j.tibs.2006.12.007 | DOI Listing |
J Cutan Aesthet Surg
December 2022
Mukhtar Skin Centre, Katihar, Bihar, India.
A stable and less voluminous nail dressing is required after nail surgery over the nail unit. The bandage should take care of trauma, water and discharge from the wound. We described the use of two layered non-sticky and absorptive bandages.
View Article and Find Full Text PDFIn Vivo
October 2024
Department of Radiotherapy, University Medical Center Schleswig-Holstein/Lübeck, Lübeck, Germany;
Background/aim: Xerostomia following (chemo-) radiotherapy (CRT) is common in head and neck (HNC) patients. This prospective study focused on investigating the link between salivary gland function and the onset of malnutrition in HNC patients.
Patients And Methods: Between 2018 and 2020, 61 HNC patients scheduled for curative CRT were prospectively recruited.
J Chem Phys
October 2024
Dipartimento di Fisica & Astronomia and INFN, Sezione di Firenze, Università di Firenze, Via G. Sansone 1, 50019 Sesto Fiorentino, Italy.
Front Robot AI
September 2024
Keio University Graduate School of Media Design, Yokohama, Japan.
J Pharm Sci
September 2024
Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda 151001, Punjab, India. Electronic address:
Burn injuries worldwide pose significant health risks due to frequent microbial infections, which worsen complications and increase mortality rates. The conventional antimicrobial formulations are available in the form of ointments and creams. These formulations are very greasy and stick to the clothes.
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