AI Article Synopsis
- The Drosophila heart, or dorsal vessel, is crucial for hemolymph circulation and offers insights into heart development due to its simple structure that resembles early vertebrate heart stages.
- Research on Drosophila heart morphogenesis has highlighted key regulators and genetic pathways involved in cardiac cell specification, differentiation, and overall organ formation and function.
- Advancements in genome-based strategies are expected to enhance the use of Drosophila for discovering new genes and regulatory networks vital for proper cardiac development and function.
Article Abstract
The Drosophila heart, also called the dorsal vessel, is an organ for hemolymph circulation that resembles the vertebrate heart at its transient linear tube stage. Dorsal vessel morphogenesis shares several similarities with early events of vertebrate heart development and has proven to be an insightful system for the study of cardiogenesis due to its relatively simple structure and the productive use of Drosophila genetic approaches. In this review, we summarize published findings on Drosophila heart development in terms of the regulators and genetic pathways required for cardiac cell specification and differentiation, and organ formation and function. Emerging genome-based strategies should further facilitate the use of Drosophila as an advantageous system in which to identify previously unknown genes and regulatory networks essential for normal cardiac development and function.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.semcdb.2006.12.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!