Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the basis of MS data and extensive NMR studies.
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Alkaloids from Sarcomelicope megistophylla.
Fitoterapia
February 2007
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, University of Athens, Athens 15771, Greece.
Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the basis of MS data and extensive NMR studies.
View Article and Find Full Text PDFEstrogenic activity of phenylpropanoids from Sarcomelicope megistophylla and structure determination of a new norneolignan.
Planta Med
June 2003
Department of Pharmacy, Laboratory of Pharmacognosy, University of Athens, Athens, Greece.
Bioassay-guided fractionation of the neutral extract of the bark of Sarcomelicope megistophylla resulted in the isolation of the new nor-neolignan sarcomeginal ( 1), together with the known ailanthoidol ( 2) and (+/-)-seco-isolariciresinol ( 3). The structure of 1 was determined by spectroscopic means. Estrogenic activity of the isolated compounds was tested using estrogen receptor-positive MCF7 and estrogen receptor-negative MDA-MB-231 human mammary adenocarcinoma cell lines.
View Article and Find Full Text PDFMegistoquinones I and II, two quinoline alkaloids with antibacterial activity from the bark of Sarcomelicope megistophylla.
Chem Pharm Bull (Tokyo)
March 2002
Department of Pharmacy, University of Athens, Greece.
Two alkaloids, megistoquinone I (1) and megistoquinone II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to quinoline alkaloid series and should be considered as oxidation products of a furo[2,3-b]quinoline precursor.
View Article and Find Full Text PDFFuromegistines I and II, two furanopyridine alkaloids from the bark of Sarcomelicope megistophylla.
Phytochemistry
June 2001
Department of Pharmacy, University of Athens, Greece.
Two alkaloids, furomegistine I (1) and furomegistine II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to the category of furanopyridine alkaloids and should be considered as oxidation products of a furo[2,3-b]quinoline precursor.
View Article and Find Full Text PDFMegistolactone, a new alkaloid from Sarcomelicope megistophylla.
Z Naturforsch C J Biosci
March 2001
Department of Pharmacy, University of Athens Panepistimiopolis Zografou, Greece.
A new quinolone alkaloid, megistolactone (1) was isolated from the bark of Sarcomelicope megistophylla. Its structure has been elucidated on the basis of MS and NMR data. From a biogenetic point of view, this compound should be considered as an oxidation product of 1,2,3,4-tetra-O-subsituted acridone alkaloids, which are also present in the bark.
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