AI Article Synopsis
- The study aimed to explore the relationship between alcoholism, aggression, and serotonin transporter (SERT) densities in the brain.
- Thirty alcoholic inpatients were divided into aggressive and nonaggressive groups based on hostility scores, and their SERT levels were compared with 18 healthy controls using PET scans.
- Results showed no significant differences in SERT binding among the groups, suggesting that unlike previous studies, SERT density may not be altered in alcoholic patients.
Article Abstract
Objective: Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics.
Methods: Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were classified as aggressive or nonaggressive based on a comparison between the top third and bottom third scores on the Buss-Durkee Hostility Index.
Results: Using a pixel-wise comparison, no brain region showed significant alterations in SERT binding among the 3 groups of subjects (aggressive alcoholic subjects, nonaggressive alcoholic subjects, and healthy controls) or between the combined alcoholic group and healthy controls. None of the clinical measures (including measures of aggression) correlated with SERT binding in the alcoholic subjects.
Conclusion: Contrary to prior imaging reports using the nonselective ligand [(123)I]beta-CIT, we found no significant alterations of SERT density in alcoholic patients.
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| http://dx.doi.org/10.1111/j.1530-0277.2006.00261.x | DOI Listing |
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