In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors. These transcription factors must function within the context of chromatin to activate or repress target genes. Recent evidence suggests that chromatin-remodeling and -modifying factors may have tissue-specific function. Here we review the potential roles for chromatin-remodeling and -modifying proteins in the development of the mammalian heart.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917192 | PMC |
| http://dx.doi.org/10.1100/tsw.2006.315 | DOI Listing |
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