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Acute electrical stimulation of the common peroneal nerve (cPNS) has been shown to cause an immediate reduction in systolic blood pressure (SBP) in spontaneous hypertense rats (SHR), but the effect of this treatment in sub-chronic ambulatory SBP is unknown. Here we developed an implantable wireless WNClip neural stimulator to test the efficacy of 5-week cPNS as a treatment for hypertension. Daily cPNS 2 Hz monophasic stimulation at threshold for 8 minutes every day for five weeks, reduced SBP in WKY animals by -4 mm Hg, and in SHR animals by -21 mmHg in week 5 (p < 0.
View Article and Find Full Text PDFAlterations in platelet activity and endothelial glycocalyx biomarkers by treatment with an angiotensin converting enzyme inhibitor or an alpha-1 adrenoceptor antagonist in patients with hypertension: results from the DoRa study.
Platelets
December 2024
Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden.
Drugs blocking the renin-angiotensin-aldosterone system may offer benefit on endothelial function, inflammation, and hemostasis in addition to the effects of reducing blood pressure. We have shown antithrombin effects by treatment with the angiotensin converting enzyme (ACE) inhibitor ramipril. As thrombin is a key inducer of platelet aggregation, we hypothesized that treatment with ramipril could modulate platelet reactivity and endothelial glycocalyx (eGCX) function.
View Article and Find Full Text PDFA randomized controlled trial on the efficacy and safety of a calcium-channel blocker and an angiotensin-converting enzyme inhibitor in Chinese and European patients with hypertension.
Am J Hypertens
December 2024
IRCCS, Istituto Auxologic Italliano, Department of Cardiology, San Luca Hospital, Milan, Italy.
Article Synopsis
- - The study examined how effective and safe nifedipine GITS and ramipril are for treating hypertension in Chinese versus European patients through a post-hoc analysis of a multinational trial.
- - The research found that while both medications reduced blood pressure similarly across ethnic groups, ethnic differences impacted age, body mass index, and certain blood pressure measurements, and the response to treatment varied between the two groups.
- - The safety profiles noted significant differences, with fewer adverse events in Chinese patients taking nifedipine, while Europeans experienced more ankle edema with nifedipine and dry cough with ramipril.
Effect of single-pill versus free equivalent combinations on persistence and major adverse cardiovascular events in hypertension: a real-world analysis.
J Hypertens
December 2024
Metabolic Centre, South-Buda Centrum Hospital - St. Imre University Teaching Hospital, Budapest, Hungary.
Objectives: Hypertension guidelines recommend the use of single-pill combinations (SPCs) of antihypertensive drugs to improve treatment persistence and blood pressure control. This study aimed to investigate the long-term effects of ramipril/amlodipine (R/A) SPC versus free equivalent dose combinations (FEC) on cardiovascular outcomes and treatment persistence.
Methods: This retrospective, observational study analysed the database of the Hungarian National Health Insurance Fund.
SGLT2i and GLP1-RA exert additive cardiorenal protection with a RAS blocker in uninephrectomized db/db mice.
Front Pharmacol
October 2024
Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Nephrology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Introduction: Diabetic Kidney Disease (DKD) is the main cause of end-stage renal disease in the developed world. The current treatment of the DKD with renin-angiotensin system (RAS) blockade does not totally halt the progression to end stage kidney disease. Currently, several drugs have shown to delay DKD progression such as sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like-1 receptor agonists (GLP-1RA).
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