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Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline.
Biologics
December 2024
School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
The successful progression of therapeutic antibodies and other biologics from the laboratory to the clinic depends on their possession of "drug-like" biophysical properties. The techniques and the resultant biophysical and biochemical parameters used to characterize their ease of manufacture can be broadly defined as developability. Focusing on antibodies, this review firstly discusses established and emerging biophysical techniques used to probe the early-stage developability of biologics, aimed towards those new to the field.
View Article and Find Full Text PDFOptical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.
Pathol Int
December 2024
Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Histopathological diagnosis is the definitive method for the evaluation of disease status; however, some problems need to be solved, such as invasiveness, time consumption, and difficulty in three-dimensional observation. To overcome these problems, a novel observation method, distinct from conventional histology, using tissue sections and glass slides is desirable. Fluorescence imaging of human tissues with multiphoton excitation imaging (MpEI), which was originally used for intravital imaging in biological research, is a promising method.
View Article and Find Full Text PDFBarriers and Facilitators for Bringing Model-Informed Precision Dosing to the Patient's Bedside: A Systematic Review.
Clin Pharmacol Ther
December 2024
Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
Article Synopsis
- Model-informed precision dosing (MIPD) uses mathematical models to determine the best medication doses for individual patients, but challenges in its implementation prevent broader use in healthcare.
- A systematic review analyzed 15 articles to identify 72 barriers and facilitators impacting MIPD's integration, highlighting issues such as limited data for model validation and unclear regulatory guidelines.
- Key facilitators include the creation of user-friendly MIPD tools and collaborative efforts among stakeholders, along with educating healthcare providers to support MIPD in clinical settings.
Interprofessional Education in Neurology Intensive Care Unit: Learning Activity for Students Completing Clerkships and Field Experiences.
MedEdPORTAL
November 2024
Professor, Department of Medical Education, East Tennessee State University Quillen College of Medicine.
Introduction: Teaching learners the benefits and challenges of interprofessional collaborative practice (IPCP) in acute care is best done in the context of authentic patient care rather than classroom settings. Yet differing clinical schedules of students and faculty as well as structured, controlled environments of intensive care units are not conducive to bringing multiple interprofessional learners to the bedside.
Methods: We developed a 2.
Ethics in humanitarian settings-relevance and consequences for dialysis and kidney care.
Clin Kidney J
October 2024
Istanbul University, Istanbul School of Medicine, Department of Nephrology, Istanbul, Turkey.
With the increasing frequency and severity of disasters and the increasing number of patients living with kidney disease, on dialysis and with transplants around the world, the need for kidney care in humanitarian settings is increasing. Almost all humanitarian emergencies pose a threat to kidney health because all treatments are highly susceptible to interruption, and interruption can be deadly. Providing support for people requiring dialysis in humanitarian settings can be complex and is associated with many trade-offs.
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