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Deep Phenotyping of a Mouse Model for Hearing Instability Disorders.
Otol Neurotol
December 2024
Auditory Development and Restoration Program, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
Article Synopsis
- - The study examines hearing instability (HI) in Slc26a4-insufficient mice, suggesting that differences in ion homeostasis gene expression and activated macrophages may contribute to the disorder.
- - Researchers conducted auditory tests and compared the results from mice with HI to those without, finding significant changes in gene expression and macrophage activity in the inner ear support cells of the affected mice.
- - Findings indicate that these genetic and immune factors influence endolymphatic hydrops (EH) and endocochlear potential (EP), offering insights into HI's potential causes and its relevance to human health.
Lexical tone recognition in multi-talker babbles and steady-state noise by Mandarin-speaking children with unilateral cochlear implants or bimodal hearing.
Int J Pediatr Otorhinolaryngol
July 2024
Department of Hearing, Speech & Language Sciences, Ohio University, Athens, OH, 45701, USA; Department of Audiology and Speech-Language Pathology, Asia University, Taichung, 41354, Taiwan. Electronic address:
Background And Objectives: Lexical tone presents challenges to cochlear implant (CI) users especially in noise conditions. Bimodal hearing utilizes residual acoustic hearing in the contralateral side and may offer benefits for tone recognition in noise. The purpose of the present study was to evaluate tone recognition in both steady-state noise and multi-talker babbles by the prelingually-deafened, Mandarin-speaking children with unilateral CIs or bimodal hearing.
View Article and Find Full Text PDFNeurovascular coupling dysfunction associated with cognitive impairment in presbycusis.
Brain Commun
June 2024
Department of Medical Imaging, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Nanjing Medical University, Wuxi 214023, China.
The neuropathological mechanism underlying presbycusis remains unclear. This study aimed to illustrate the mechanism of neurovascular coupling associated with cognitive impairment in patients with presbycusis. We assessed the coupling of cerebral blood perfusion with spontaneous neuronal activity by calculating the correlation coefficients between cerebral blood flow and blood oxygen level-dependent-derived quantitative maps (amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, regional homogeneity, degree centrality).
View Article and Find Full Text PDF[Cochlear implantation in patients with autoimmune hearing loss].
HNO
January 2025
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikum Regensburg, Regensburg, Deutschland.
Article Synopsis
- Autoimmune inner ear disease (AIED) leads to fluctuating hearing loss and may require cochlear implants (CIs) for rehabilitation, but treatment can affect results.
- A case study of a 25-year-old male showed that after receiving a CI, his hearing impedances fluctuated significantly, particularly with the use of the TNFα inhibitor adalimumab.
- The findings suggest that maintaining immunomodulatory therapy is important for stabilizing hearing outcomes in AIED patients with CIs, as it can help reduce impedances and improve overall hearing quality.
Decoding auditory deprivation: resting-state fMRI insights into deafness and brain plasticity.
Brain Struct Funct
April 2024
Centre of Bio-Medical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, Uttar Pradesh, 226014, India.
Deafness, as a profound manifestation of sensory deprivation, prompts a cascade of intricate cerebral adaptations. In this study, involving 35 deaf individuals and 35 hearing controls, we utilized resting-state functional magnetic resonance imaging (rs-fMRI) to delve into the depths of functional connectivity nuances distinguishing deaf individuals from their hearing counterparts. Leading our analytical approach was the application of multi-voxel pattern analysis (fc-MVPA).
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