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Chemotherapy alters thrombomodulin and factor VIIIc expression resulting in acquired activated protein C resistance and enhanced thrombin generation in cancer associated thrombosis.
Thromb Res
December 2024
Department of Obstetrics and Gynaecology, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, Dublin, Ireland. Electronic address:
Background: Tumour type, treatment and patient related factors contribute to cancer associated venous thromboembolism (VTE), however, the role of each factor and the mechanisms involved are not understood.
Aim: To assess the role of the tumour, and of chemotherapy, in mediating the procoagulant response associated with VTE in gynaecological cancer patients.
Methods: Gynaecological cancer patients who developed VTE during follow-up (n = 59) (VTE+) were matched with treatment naïve(treatment (-)(VTE-)(n = 120) and chemotherapy treated patients(treatment (+)(VTE-) (n = 57)).
Thrombomodulin - A key regulator of intravascular blood coagulation and inflammation, and a treatment for disseminated intravascular coagulation.
Proc Jpn Acad Ser B Phys Biol Sci
December 2024
Professor, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan.
Thrombomodulin (TM) is an important regulator of intravascular blood coagulation and inflammation. TM inhibits the procoagulant and proinflammatory activities of thrombin and promotes the thrombin-induced activation of protein C (PC) bound to the endothelial PC receptor (EPCR). Activated PC (APC) inactivates coagulation factors Va and VIIIa, thereby inhibiting blood clotting.
View Article and Find Full Text PDFImpact of Hypothermic Perfusion on Immune Responses and Sterile Inflammation in a Preclinical Model of Pancreatic Transplantation.
Transplant Direct
January 2025
Department of Urology and Transplantation Surgery, Nantes University Hospital, Nantes, France.
Background: In organ transplantation, cold ischemia is associated with sterile inflammation that subsequently conditions adaptive immunity directed against the grafts during revascularization. This inflammation is responsible for venous thrombosis, which is the main postoperative complication affecting graft function. Our aim was to investigate the modulation of immune responses and endothelial function of pancreatic grafts during cold ischemia using different preservation modalities.
View Article and Find Full Text PDF[AI for anticoagulant therapy for patients with sepsis-induced DIC: issues and future direction of identifying sepsis subclass].
Rinsho Ketsueki
October 2024
Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine.
Article Synopsis
- Sepsis is a severe condition resulting from an overly reactive response to infection, with high rates of incidence and death globally, yet specific treatments remain elusive due to its complexity.
- Various studies have attempted to categorize sepsis into subclasses based on different biological markers and clinical features, although no two subclasses have consistent traits that would make them clinically applicable.
- Research continues to identify subclasses that not only reflect the underlying biological mechanisms but can also be reliably reproduced across different patient groups to improve treatment outcomes.
Targeting complement dysregulation: eculizumab in scleroderma renal crisis management-a case-based review.
Rheumatol Int
December 2024
Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098, Istanbul, Turkey.
Systemic sclerosis (SSc) poses significant challenges in clinical management, especially when complicated by scleroderma renal crisis (SRC), a rare but life-threatening manifestation. Here, we report a 41-year-old female patient with SSc who presented with SRC and concurrent thrombotic microangiopathy. Her condition persisted despite conventional treatments such as plasma exchange and renin-angiotensin-aldosterone system blockade.
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