AI Article Synopsis
- Transmissible gastroenteritis (TGE) virus was found in lung and intestinal tissues from 6 out of 9 chronic pig infections even after 30 to 104 days post-inoculation.
- Tissue samples from these pigs, when used to infect gnotobiotic pigs, showed that the virus caused milder illness on the first try and more severe illness upon further passages.
- Serum-neutralization titers in the infected pigs ranged widely, but there was no clear link between these titers and the detection of TGE virus, suggesting that carrier pigs could be a major source of TGE infection.
Article Abstract
Transmissible gastroenteritis (TGE) virus was reisolated from pulmonary and intestinal tissues from 6 of 9 chronically infected experimental pigs (principals) necropsied 30 to 104 days after inoculation. Tissue homogenates (lung and small intestine) from the principals were prepared and inoculated into 3- to 5-day-old gnotobiotic pigs. The virus reisolated from the tissue homogenates produced a milder disease on 1st passage and a more severe disease on 2nd passage. The chronically infected experimental pigs (principals) developed serum-neutralization titers to TGE of 1:30 to 1:525. There appeared to be no relationship between serum titers and reisolation of TGE virus from the 9 principals. The persistence of virus in lung or intestine to 104 days indicates the recovered (or carrier) pig may be considered the primary source of TGE virus infection.
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