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Inhibition of EphA2 by syndecan-4 in wounded skin regulates clustering of fibroblasts.
J Mol Cell Biol
December 2024
School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom.
Upon injury, fibroblasts in the surrounding tissue become activated, migrating into the wound in a controlled manner. Once they arrive, they contract the wound and remodel the stroma. While certain cell surface receptors promote fibroblast migration, others cause repulsion between fibroblasts upon contact, seemingly opposing their clustering within the wound bed.
View Article and Find Full Text PDFSNAI1 promotes epithelial-mesenchymal transition and maintains cancer stem cell-like properties in thymic epithelial tumors through the PIK3R2/p-EphA2 Axis.
J Exp Clin Cancer Res
December 2024
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200443, China.
Background: Thymic epithelial tumors (TETs) are infrequent malignancies that arise from the anterior mediastinum. Therapeutic options for TETs, especially thymic carcinoma (TC), remain relatively constrained. This study aims to investigate the oncogenic hub gene and its underlying mechanisms in TETs, as well as to identify potential therapeutic targets.
View Article and Find Full Text PDFComputational deconvolution of cell type-specific gene expression in COPD and IPF lungs reveals disease severity associations.
BMC Genomics
December 2024
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA, 181 Longwood Ave, 02115, MA.
Background: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes in the lungs. At present, due to cost and technical limitations, profiling cell types is not practical in large epidemiology cohorts (n > 1000). Here, we used computational deconvolution to identify cell types in COPD and IPF lungs whose abundances and cell type-specific gene expression are associated with disease diagnosis and severity.
View Article and Find Full Text PDFSHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation.
Cell Death Dis
December 2024
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.
The macrophage-associated inflammation response plays an important role in myocardial ischemia-reperfusion injury (MIRI). SHEP1(SH2 domain-containing Eph receptor-binding protein 1) has been implicated in adhesion and migration of inflammatory cells. However, the role and molecular mechanism of SHEP1 regulating macrophage remains unclear during MIRI.
View Article and Find Full Text PDFEFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma.
Apoptosis
December 2024
Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, 510315, China.
Article Synopsis
- EFNA4 influences liver cancer (HCC) through two mechanisms: one that binds to Eph receptors and another that operates independently of them.
- Despite a lack of Eph receptors, EFNA4 still promotes HCC cell growth and spread as well as inhibiting ferroptosis, a type of cell death.
- The study reveals that EFNA4 interacts with the protein SLC7A11 to prevent its degradation, enhancing HCC progression and suggesting EFNA4 as a potential marker and target for HCC treatment.
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