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ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer's disease.
Geroscience
November 2024
Department of Neurology, Louisiana State University Health, LSU Health Sciences Center Shreveport, 1501 Kings Hwy, Shreveport, LA, 71103-3932, USA.
Alzheimer's disease (AD), the leading cause of dementia, affects over 55 million people worldwide and is often accompanied by depression and anxiety. Both significantly impact patients' quality of life and impose substantial societal and economic burdens on healthcare systems. Identifying the complex regulatory mechanisms that contribute to the psychological and emotional deficits in AD will provide promising therapeutic targets.
View Article and Find Full Text PDFThe interplay between diet and the enteric nervous system in the pathophysiology of colorectal cancer.
Folia Med Cracov
September 2024
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Łódź, Poland.
Colorectal cancer (CRC) represents the third most diagnosed cancer worldwide, with 1.9 million new cases reported annually. Notwithstanding the progress made in the field of therapeutic modalities and the advent of early diagnosis, CRC continues to represent the second most common cause of cancer-related mortality.
View Article and Find Full Text PDFCan Omega-3 prevent the accidence of stroke: a mendelian randomization study.
Hereditas
September 2024
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: The lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as saturated fatty acids in cardiovascular diseases, including hypertension and ischemic stroke, are less frequent.
Objectives: This study aims to identify fatty acids associated with blood pressure and ischemic stroke through Mendelian randomization.
Cannabigerol as an anti-inflammatory agent altering the level of arachidonic acid derivatives in the colon tissue of rats subjected to a high-fat high-sucrose diet.
Biomed Pharmacother
September 2024
Department of Physiology, Medical University of Bialystok, Bialystok, Poland. Electronic address:
Article Synopsis
- Fat and sugar overconsumption contributes to rising rates of inflammatory conditions in the gastrointestinal tract, but early changes in the intestine may be reversible, potentially reducing colitis risk.
- This study tested the effects of cannabigerol (CBG) on colonic inflammation in rats fed either standard or high-caloric diets over six weeks, with half receiving CBG treatment for the last two weeks.
- Results showed that CBG decreased inflammation markers and altered fatty acid ratios, suggesting it may help protect against colonic inflammation caused by excessive fat and sugar intake.
From the kitchen to the medicine cabinet: Examples of food products and supplements used for therapeutic intent.
J Pediatr Gastroenterol Nutr
September 2024
Pediatric Gastroenterology, Hepatology and Nutrition, Salah Foundation Children Hospital at Broward Health, Fort Lauderdale, Florida, USA.
"Food as medicine" has existed for centuries as the foundation of health for many cultures around the globe. It is a practice built on the knowledge that food and diet play important roles in disease prevention and management. Foods that claim to have therapeutic properties are often referred to as functional foods.
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