AI Article Synopsis
- Rare cases of acute promyelocytic leukemia (APL) can involve a specific genetic translocation (t(11;17)) leading to the PLZF-RARalpha fusion transcript, which can reduce the effectiveness of ATRA treatment.
- An 83-year-old patient with this rare APL variant was successfully treated using ATRA and Daunorubicin.
- The study utilized a quantitative RT-PCR method to effectively monitor and confirm the patient's molecular response to treatment.
Article Abstract
Rare cases of acute promyelocytic leukemia (APL) are associated with a t(11;17) translocation and a PLZF-RARalpha fusion transcript. Because of molecular specificities of the fusion protein, ATRA efficiency is often reduced in these cases. We present herein the case of an 83-year old patient which has been successfully treated by ATRA and Daunorubicin. The described quantitative RT-PCR method allowed successful monitoring and confirmation of the molecular response.
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