We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relative to the other two species, the chimpanzee cluster has remained surprisingly similar to the human cluster, given the evolutionary volatility of this gene family. The comparison will allow us to further refine our model of the evolution of this gene family in mammals.
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Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species.
Genetica
June 2008
Department of Zoology, Miami University, Oxford, OH, 45056, USA.
The evolution of gene families can be best understood by studying the modern organization and functions of family members, and by comparing parallel families in different species. In this study, the CYP2ABFGST gene cluster has been characterized in rat and compared to the syntenic clusters in mouse and human, providing an interesting example of gene family evolution. In the rat, 18 loci from six subfamilies have been identified by specifically amplifying and sequencing gene fragments from cloned DNA, and have been exactly placed on chromosome 1.
View Article and Find Full Text PDFDynamic evolution of the CYP2ABFGST gene cluster in primates.
Mutat Res
March 2007
Department of Zoology, Miami University, Oxford, OH 45056, USA.
We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relative to the other two species, the chimpanzee cluster has remained surprisingly similar to the human cluster, given the evolutionary volatility of this gene family. The comparison will allow us to further refine our model of the evolution of this gene family in mammals.
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