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Pityriasis rubra pilaris (PRP) presents a diagnostic challenge due to its varied clinical manifestations and the scarce literature on scalp involvement. This article presents a case report of a 59-year-old female with PRP solely affecting the scalp, detailing its clinical, trichoscopic, and histopathological features. Trichoscopy revealed a novel finding of white-silvery scales forming hair casts with a triangular shape, distinct from the existing literature.

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  • Autosomal recessive congenital ichthyosis (ARCI) is a rare skin condition primarily characterized by skin scaling and hair abnormalities, which are often overlooked regarding their impact on patients' quality of life.
  • This study involved clinical and trichoscopic examinations of 30 ARCI patients over three years, revealing that alopecia affects a significant number, with various patterns of hair loss documented among participants.
  • Notable trichoscopic findings included scaling and different hair types that correlate with the severity of ARCI, suggesting that hair health is a crucial component of this condition often underestimated in prior research.
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CASTing the net wider: A case report of PLACK syndrome associated with dilated cardiomyopathy.

Pediatr Dermatol

November 2024

Department of Internal Medicine, Division of Dermatology, Dell Medical School, University of Texas, Austin, Texas, USA.

Article Synopsis
  • PLACK syndrome is a rare genetic skin condition associated with symptoms like peeling skin, white nails, and knuckle pads, caused by mutations in the CAST gene that affects a specific protease.
  • This case report discusses a patient with PLACK syndrome who showed unusual palm hyperkeratosis and developed serious heart issues, specifically cardiomyopathy.
  • The report emphasizes the need to understand how CAST mutations can affect heart health and highlights the possible links between PLACK syndrome and cardiac problems.
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  • Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women, with ongoing research into why this gender disparity exists and how ethnicity may affect the disease's clinical features.
  • A study of 89 childhood-onset SLE patients revealed that males had more instances of serositis and elevated anti-DNA antibodies, while females experienced more hair loss and lower average hemoglobin levels.
  • Despite differences in treatment, renal involvement appeared more commonly in males, indicating a need for further exploration of gender-specific manifestations and treatments in cSLE cases.
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  • - Hair disorders like central centrifugal cicatricial alopecia (CCCA), traction alopecia (TA), and acquired trichorrhexis nodosa (ATN) frequently affect people with curly hair, particularly those of African descent, due to the unique characteristics of their hair.
  • - CCCA has associations with conditions such as uterine leiomyoma and type 2 diabetes, while TA is linked to high-tension hairstyles, and both require careful diagnosis using trichoscopy to identify specific signs like perifollicular halos and miniaturized follicles.
  • - This review highlights the impact of hairstyling practices on these conditions, addresses mixed findings related to chemical relaxers and heat styling, and includes new insights into issues
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