A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens.

J Enzyme Inhib Med Chem

Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

Published: October 2006

Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. and Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 microM.

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http://dx.doi.org/10.1080/14756360600586072DOI Listing

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