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Dual Template Molecularly Imprinted Polymers Targeting Blockade of CD47 for Enhanced Macrophage Phagocytosis and Synergistic Antimetabolic Therapy.
ACS Appl Mater Interfaces
August 2024
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China.
Glycinamide ribonucleotide formyltransferase (GARFT) is an important enzyme in the folate metabolism pathway, and chemical drugs targeting GARFT have been used in tumor treatments over the past few decades. The development of novel antimetabolism drugs that target GARFT with improved performance and superior activity remains an attractive strategy. Herein, we proposed a targeted double-template molecularly imprinted polymer (MIP) for enhancing macrophage phagocytosis and synergistic antimetabolic therapy.
View Article and Find Full Text PDFUltrasonic Preparation of Nano-CaCO Templates and Hollow Mesoporous SiO Nanoparticles for Voriconazole Loading.
AAPS PharmSciTech
July 2024
Department of Drug Science and Technology and NIS - Centre, University of Turin, Via Pietro Giuria 9, Turin, 10125, Italy.
Article Synopsis
- Researchers created calcium carbonate (CaCO) nanoparticles as templates and used them to produce hollow mesoporous silica nanoparticles (HMSNs) for drug delivery.
- The HMSNs, with a high surface area and specific pore structure, effectively encapsulated the antifungal drug voriconazole (VOR), with a loading capacity of nearly 8%.
- The study found that VOR release from the HMSNs followed Fickian diffusion, with higher cumulative release at elevated temperatures and lower pH levels.
Functionalized nano cellulose double-template imprinted aerogel microsphere for the targeted enrichment of taxanes.
Int J Biol Macromol
July 2024
The College of Forestry, Beijing Forestry University, 100083 Beijing, PR China. Electronic address:
Paclitaxel, a diterpenoid isolated from the bark of Taxus wallichiana var. chinensis (Pilger) Florin, is currently showing significant therapeutic effects against a variety of cancers. Baccatin III (Bac) and 10-Deacetylbaccatin III (10-DAB) are in great demand as important precursors for the synthesis of paclitaxel.
View Article and Find Full Text PDFSynthesis of hierarchical porous zirconium dioxide and its application in the detection of sulfonamides in animal-derived food.
Anal Methods
December 2022
College of Chemistry and Chemical Engineering, Yantai University, Yantai, China.
In order to effectively remove grease for the detection of sulfonamides, a non-toxic and low-cost hierarchical porous zirconia material was synthesized using the dual template method. The lipid impurities in an animal-derived food matrix can be absorbed by hierarchical zirconia. A ZrO prepolymer was synthesized by mixing amphiphilic triblock copolymer poly(ethylene glycol)--poly(propylene glycol)--poly(ethylene glycol) (P123) with tannin extract as the double template and Zr(SO) as the metal source.
View Article and Find Full Text PDFControllable Synthesis of Modified Porous Anatase TiO₂ with High Photocatalytic Activity.
J Nanosci Nanotechnol
November 2021
Institute for Interdisciplinary Biomass Functional Materials Studies, Jilin Engineering Normal University, Changchun, 130052, P. R. China.
In this study, we added ZrO₂ and Y₂O₃ to stabilize the anatase TiO₂ phase at higher temperatures. Composite mesoporous TiO₂/ZrO₂/Y₂O₃ (TZY) oxides were prepared by a sol-gel method, and triblockcopolymer P123 and PEG was used as templates. The properties of the synthesized materials were characterized using X-Ray diffraction (XRD), Raman scattering, N₂ adsorption/desorption, and UV-Visible spectrophotometry (UV-Vis) methods et al.
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