AI Article Synopsis
- Mixtures of amphiphilic cholesteryl phosphate (CP), sitosteryl phosphate (SP), or cholesteryl phosphocholine (CPC) with dimyristoylglycerol (DMG) or cholesterol create giant vesicles that self-organize across various pH levels.
- The study used techniques like fluorescence microscopy and small-angle X-ray scattering to observe these systems and measured water permeability in a specific mixture of CPC and DMG.
- These self-organized systems resemble natural eukaryotic membranes but differ in the location of their phosphate group, suggesting they could exist in unstudied organisms.
Article Abstract
Mixtures of amphiphilic cholesteryl phosphate (CP), sitosteryl phosphate (SP), or cholesteryl phosphocholine (CPC) with the nonphosphoryl diacyl lipid dimyristoylglycerol (DMG) or with cholesterol give self-organized systems (giant vesicles) in a wide range of pH, as demonstrated by fluorescence microscopy, differential scanning calorimetry, and small-angle X-ray scattering. The water permeability of a 1 : 1 molar mixture of CPC and DMG was also measured by a stopped-flow/light-scattering method. The novel self-organized systems are akin to natural eukaryotic ones, the only difference being the site of the phosphate-containing head-group, located on cholesterol instead of DMG. They might be present in some organisms not yet studied for the composition of their membranes.
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| http://dx.doi.org/10.1002/cbdv.200690023 | DOI Listing |
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