AI Article Synopsis
- The study investigates the activation of the hedgehog (Hh) signaling pathway in gastric cancer to explore its potential as a therapeutic target.
- Researchers analyzed cancer specimens for the presence of Gli1, a marker indicating Hh pathway activation, finding higher levels in undifferentiated-type tumors compared to differentiated-type tumors.
- The findings suggest that targeting the Hh pathway, specifically in undifferentiated gastric cancers with lymph node metastasis, could be a promising treatment approach.
Article Abstract
Background And Objectives: It has been shown that the hedgehog (Hh) signaling pathway is activated in gastric cancer. To investigate the viability of the Hh pathway as a therapeutic target, we analyzed activation of the Hh pathway in gastric cancer.
Methods: Surgically resected gastric carcinoma specimens and lymph nodes were analyzed immunohistochemically. We used the percentage of cancer cells with nuclear translocation of Gli1 as a marker of Hh pathway activation.
Results: Nuclear localization of Gli1 was higher in 28 undifferentiated-type tumors than in 30 differentiated-type tumors. Eighteen of the fifty-eight cancer specimens consisted of a mixture of a histologically predominant part and a small area with different histology. In these 18 tumors, the percentage of cells showing nuclear staining of Gli1 was higher in the undifferentiated-type part than in the differentiated-type part. Nuclear staining of Gli1 in primary tumors was positively correlated with lymph node metastasis. The Gli1 nuclear staining percentage of metastatic lymph nodes correlated closely with that of each primary carcinoma. Cyclopamine, a Hh pathway inhibitor, suppressed the growth of gastric cancer cells in vitro.
Conclusions: The Hh pathway may be a useful therapeutic target for such as undifferentiated-type gastric cancer with lymph node metastasis.
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| http://dx.doi.org/10.1002/jso.20606 | DOI Listing |
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