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Hepatitis B vaccine and risk of autoimmune thyroid disease: a Vaccine Safety Datalink study. | LitMetric

AI Article Synopsis

  • The study aimed to investigate whether the hepatitis B vaccine is linked to autoimmune thyroid diseases (ATD), specifically Graves' disease and Hashimoto's thyroiditis, using data from the Vaccine Safety Datalink project.
  • Researchers analyzed medical records from health maintenance organizations, enrolling 355 cases of Graves' disease, 418 cases of Hashimoto's thyroiditis, and 1102 controls to assess vaccination history.
  • The findings showed no increased risk of developing either Graves' disease or Hashimoto's thyroiditis among those who received the hepatitis B vaccine, regardless of the time since vaccination.

Article Abstract

Purpose: Hepatitis B vaccine has been postulated as a possible cause of autoimmune disorders, including autoimmune thyroid diseases (ATD). Cases of Graves' disease and Hashimoto's thyroiditis, following hepatitis B vaccine have been reported to the Vaccine Adverse Events Reporting System (VAERS). To test the hypothesis that hepatitis B vaccine increases the risk of ATD, we conducted a case-control study, within the Vaccine Safety Datalink project.

Methods: We identified potential cases of Graves' disease and Hashimoto's thyroiditis, among persons aged 18-69 years from administrative data recorded by three health maintenance organizations (HMOs) and verified cases by medical record review. Controls were frequency-matched to cases by birth year, sex, and study site. Vaccine information was collected from administrative records, chart review, and telephone interviews with study subjects. We enrolled 355 Graves' disease cases, 418 Hashimoto's thyroiditis cases, and 1102 controls. We assessed the association between ever-receipt of hepatitis B vaccine, as well as receipt of hepatitis B vaccine less than 1 year, 1-5 years and at least 5 years prior to the index date, and the risk of ATD.

Results: Ever-receipt of hepatitis B vaccine was not associated with risk of Graves' disease (odds ratio (OR), 0.90; 95% confidence interval (CI), 0.62-1.32) or Hashimoto's thyroiditis (OR, 1.23; 95%CI, 0.87-1.73). There was also no association between the time interval since receipt of hepatitis B vaccination and either outcome.

Conclusions: We did not observe an increased risk of Graves' disease or Hashimoto's thyroiditis, following receipt of hepatitis B vaccine.

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Source
http://dx.doi.org/10.1002/pds.1354DOI Listing

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