AI Article Synopsis
- The study explored the relationship between asymptomatic spontaneous cerebral emboli (SCE) and cognitive decline in older adults without dementia.
- Over 2.5 years, 96 participants were assessed, showing no significant link between SCE presence and changes in cognitive scores (MMSE and CAMCOG).
- Instead, factors like older age, previous strokes, and carotid stenosis were identified as key predictors of cognitive decline, not SCE.
Article Abstract
Background: Asymptomatic spontaneous cerebral emboli (SCE) are common in dementia and are associated with cognitive decline in dementia. The significance of their presence in older people is unknown.
Method: We included 96 participants (mean (SD) age 76.8 (6.7) years, 46% female) who were the control group in a case-control study to evaluate SCE in dementia. Cognitive functioning was assessed prospectively over 2.5 years, using the MMSE and CAMCOG.
Results: The mean (SD) MMSE score was 28.7 (1.4) at baseline with an average (SD) drop of 0.79 (0.91) per year. The presence of SCE was not related to the annual drop in MMSE score, nor to the CAMCOG score at follow-up (p = 0.88 and p = 0.41, respectively). Linear regression analyses identified higher age in years (beta = 0.29, p = 0.003), history of stroke (beta = 0.31, p = 0.001) and carotid stenosis (beta = 0.28, p = 0.003) as independent predictors of cognitive decline.
Conclusion: We found no association between the presence of SCE and subsequent cognitive decline in older people without dementia.
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| http://dx.doi.org/10.1002/gps.1744 | DOI Listing |
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