Synthesis of encoded modified oligonucleotide libraries. Part 1: orthogonal chemistry.

Chem Biodivers

Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET-UBA, Vuelta de Obligado 2490, Buenos Aires, Argentina.

Published: April 2004

The basis for further development of combinatorial libraries of modified oligonucleotides tagged by a codifying sequence is discussed. The chemistry involved in the orthogonal synthesis of both strands and some representative examples of building blocks are presented.

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http://dx.doi.org/10.1002/cbdv.200490049DOI Listing

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