A prognostic score was developed in the course of treatment of 551 pediatric patients with Hodgkin's disease stage I-IV (1967-2001). It took care of such significant factors of uni-and multivariate analysis as age (11 years or more), peripheral lymph node involvement (5cm or more), systemic symptoms (B), histological pattern for lymphocytic depletion, IVB stage and/or extranodal disease (E) and biological rate of tumor process ("b"). As a result, three groups at risk were identified: favorable prognosis (65.8%: overall survival - 92%, relapse-free - 67%), medium risk (17.8%: overall survival - 67%, relapse-free 48%) and high risk (16.4%: overall survival - 38%, relapse-free 25%). Our data may be used to estimate the scope of risk-adapted therapy for Hodgkin's disease.
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