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Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341. II. Physicochemical properties and structure determination. | LitMetric
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Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341. II. Physicochemical properties and structure determination.

Won-Gon Kim Tae Mi Yoon Hyung Jin Kwon Joo Won Suh

J Antibiot (Tokyo)

Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong-Gu, Daejeon, 305-600, Korea.

Published: October 2006

In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides, with potent antifungal activity, talosins A and B, were isolated from the culture broth of Kitasatospora kifunensis MJM341. Talosins A and B were determined to be genistein 7-alpha-L-6-deoxy-talopyranoside and genistein 4',7-di-alpha-L-6-deoxy-talopyranoside, respectively, by spectroscopic studies. They are the first flavonoid glycosides incorporating 6-deoxy-talose as a sugar component.

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http://dx.doi.org/10.1038/ja.2006.85DOI Listing

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