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Meningitis or madness: a delicate balance.

J Paediatr Child Health

June 1999

Department of Paediatrics, Goroka Base Hospital, Papua New Guinea.

A child with meningitis who developed a psychosis 2 weeks after commencing treatment with antituberculous therapy is described here. The psychosis resolved with cessation of isoniazid, but the meningitis returned. The meningitis was treated by re-introduction of daily doses of isoniazid, but the psychosis recurred.

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Objective: To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect.

Data Sources: Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information.

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