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Military influences on the evolution of clinical trials throughout history.
Clin Trials
January 2025
Department of Urology, University of Rochester Medical Center, Rochester, NY, USA.
Clinical trials of drugs, procedures, and other therapies play a crucial role in advancing medical science by evaluating the safety, efficacy, and optimal use of medical interventions. The design and implementation of these trials have evolved significantly over time, reflecting advancements in medicine, ethics, and methodology. Early historical examples, such as King Nebuchadnezzar II's and his captives' dietary experiment and Ambroise Paré's treatment of gunshot wounds, laid some foundational principles of trial design.
View Article and Find Full Text PDFBallistic femoral neck fractures: Associated injuries and outcomes.
Injury
January 2025
Department of Orthopaedic Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. Electronic address:
Background: Ballistic fractures of the femoral neck, rare injuries that overwhelmingly affect younger adults, pose significant challenges to the treating surgeon. However, there is limited literature that the treating surgeon can leverage to guide their treatment decisions. The goal of this study is to describe the demographics, associated injuries, outcomes, and complications associated with ballistic femoral neck fractures.
View Article and Find Full Text PDFDiagnostic Challenges in Uncommon Firearm Injury Cases: A Multidisciplinary Approach.
Diagnostics (Basel)
December 2024
Faculty of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.
: Firearm wounds tend to have a precise pattern. Despite this, real-world case presentations can present uncertain elements, sometimes deviating from what is considered standard, and present uncommon features that are difficult for forensic pathologists and ballistic experts to explain. : A retrospective analysis of autopsy reports from the Institute of Legal Medicine, University of Catania, covering 2019-2023, included 348 judicial inspections and 378 autopsies performed as part of the institute's overall activities.
View Article and Find Full Text PDFBackground: Traumatic arteriovenous fistulas (AVFs) are rare entities, especially when referring to visceral arterioportal AVFs. Currently, there are no large epidemiological studies looking specifically at traumatic visceral AVFs. When traumatic AVFs have been discussed in the literature, it is in the form of case reports or case series and focused on peripheral AVFs.
View Article and Find Full Text PDFIntracranial Gunshot Wounds: An Assessment of Patient Characteristics on Surgical Outcomes.
Cureus
December 2024
Department of Neurosurgery, Kaiser Permanente, Redwood City, USA.
Background/objective: Intracranial gunshot wounds (GSW) are often fatal, with most patients dying before intervention can occur. Surgical management, when indicated, results in decreased mortality. We sought to assess the neurosurgical outcomes and economic costs of intracranial GSW.
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