This study provides a preliminary analysis of the Information System in the Schistosomiasis Control Program (SISPCE) in the States of Bahia, Sergipe, Alagoas, and Pernambuco, Brazil, from 1999 to 2003. The data analysis suggests a sharp decline in data entry in the system during the transition period involving health services decentralization, followed by a gradual increase. Major under-recording was observed in Pernambuco. SISPCE-DATASUS and IBGE (National Census Bureau) data are insufficient to construct a surveillance index for serious forms of the endemic disease and other aspects that could relate sanitary conditions to schistosomiasis. Reformulation of the SISPCE is key for schistosomiasis control measures, given the new reality in the Brazilian health system. The data system should be redesigned in order to integrate the health policies with the Unified National Health System's guidelines, using a systematic data collection methodology in keeping with local specificities and allowing prospective comparisons and evaluations, in addition to constructing new indicators with an emphasis on morbidity and determinants of the endemic and the adoption of analytical of the that express the real situation of the schistosomiasis in the States.
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http://dx.doi.org/10.1590/s0102-311x2007000100025 | DOI Listing |
J Clin Microbiol
January 2025
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Unlabelled: The World Health Organization (WHO) 2030 roadmap for schistosomiasis calls for development of highly sensitive and specific diagnostic tools to continue and sustain progress towards elimination. Serological assays are excellent for sensitive detection of primary schistosome infections and for schistosomiasis surveillance in near- and post-elimination settings. To develop accurate assay formats, it is necessary to identify defined antibody targets with low cross-reactivity and potential for standardized production.
View Article and Find Full Text PDFEgypt J Immunol
January 2025
Department of Medical Parasitology, Faculty of Medicine (girls), Al-Azhar University, Cairo, Egypt.
Hepato-intestinal schistosomiasis is characterized by severe pathological changes at advanced chronic stages, including granulomatous lesions and liver fibrosis. The objective of our research was to assess the dynamic expression of profibrotic molecules, the transforming growth factor beta 1 (TGF-β1), and proinflammatory cytokines immunomodulation induced by interleukin 17 (IL-17) neutralization in murine Schistosomiasis mansoni. The study included 56 specific pathogen-free male C57BL/6 mice, divided into 3 main groups: GI uninfected normal controls, GII S.
View Article and Find Full Text PDFSchistosomiasis, a neglected tropical disease, is transmitted by freshwater snails. Interruption of transmission will require novel vector-focused interventions. We performed a genome-wide association study of African snails, , exposed to in an endemic area of high transmission in Kenya.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Disease control and immunization unit, Bauchi State Primary Health Care Development Agency, Dass Emirate, Nigeria.
Objective: Schistosomiasis has been recognized by WHO as a major contributor to mortality and morbidity, particularly in Sub-Sahara Africa, where it is most prevalent. There is a lack of reliable data on the effectiveness of health education interventions in reducing the prevalence of schistosomiasis in Bauchi State. Hence, the study assessed the prevalence of schistosomiasis and the knowledge, attitude and practices of community members of Dass Emirate towards the prevention and control of schistosomiasis before and after health education intervention.
View Article and Find Full Text PDFActa Parasitol
January 2025
Federal University of São João del-Rei, Divinópolis, MG, Brazil.
Purpose: Schistosomiasis remains a parasitic disease affecting millions of people worldwide, requiring interventions like vaccination. In previous work, our group used reverse vaccinology to identify two epitopes from the Schistosoma mansoni proteins, Sm050890 (44-58) and Sm141290 (225-239). This study evaluated the immune response profile and protection induced by peptides, as a mixture of immunogens, in murine vaccination trials.
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