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Pathology of Neointimal Calcification in Very Late Restenosis After Bare Metal Stent Implantation for Superficial Femoral Artery.
Int Heart J
August 2017
Division of Cardiovascular Medicine, Kokura Memorial Hospital.
A 60-year-old man, who had claudication in his right limb due to total occlusion of the right superficial femoral artery, received bare metal stents. Although the bare metal stents in the superficial femoral artery did not show restenosis 5 years after stent implantation, angiography revealed significant in-stent restenosis when he developed right critical limb ischemia at 8 years post implantation. Ballooning for in-stent lesions did not result in full expansion.
View Article and Find Full Text PDFFabrication and characteristics of dual functionalized vascular stent by spatio-temporal coating.
Acta Biomater
July 2016
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea; Department of Biomedical Engineering, Korea University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea. Electronic address:
Article Synopsis
- Stents have evolved from bare metal types to advanced drug-eluting stents (DES), yet issues like thrombosis and restenosis remain common complications.
- A new dual-functionalized stent was created by applying a hyaluronic acid-dopamine (HA-DA) coating on a cobalt-chromium stent, followed by a sirolimus-in-polymer (P+S) layer, which effectively stabilizes the coating and prevents cracks during ballooning.
- In tests, the HA-DA coating reduced platelet adhesion and maintained cell health, and when tested in a porcine model, the dual-functionalized stent showed significantly less neointimal growth and inflammation compared to traditional bare metal stents, indicating promising potential for
Development of a biodegradable sirolimus-eluting stent coated by ultrasonic atomizing spray.
J Nanosci Nanotechnol
July 2011
Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea.
In this study, poly(D,L lactic-co-glycolic acid) (PLGA) was used as a drug carrier to generate two types of stents loaded with different concentrations of sirolimus. These stents were prepared by ultrasonic atomizing spray coating. Ultrasonic atomizing spray nozzle uses a low-pressure air/gas to produce a soft, highly focused beam of small spray drops.
View Article and Find Full Text PDFScanning electron microscopic analysis of defects in polymer coatings of three commercially available stents: comparison of BiodivYsio, Taxus and Cypher stents.
J Invasive Cardiol
February 2007
Saint Joseph's Research Institute, Atlanta, Georgia, USA.
Background: Although the use of polymer-based drug-eluting stents appears to markedly reduce the risk of in-stent restenosis, there are concerns about their safety including polymer layer integrity.
Objectives: The objective of this study was to investigate the morphology of the polymer layer of 3 commercially available polymercoated stents, including the effects of balloon catheter expansion, by scanning electron microscopy (SEM).
Methods: We assessed discontinuities and other irregularities in the polymer layer of BiodivYsio, Taxus and Cypher stents by SEM after balloon expansion in saline solution at 37 degrees C.
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