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Cytomegalovirus-associated supraglottic mass in a patient on immunosuppressive therapy.
S Afr Med J
June 2021
Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, University of the Witswatersrand, Johannesburg, South Africa.
A 33-year-old woman on chronic immunosuppressive treatment for rheumatoid arthritis with a history of inhaled methamphetamine use presented with respiratory failure requiring mechanical ventilation for a prolonged period. After being given plasma exchange, pulses of methylprednisolone and a dose of cyclosporine for suspected ANCA (anti-neutrophilic cytoplasmic autoantibodies) vasculitis, she developed an obstructive supraglottic laryngeal mass that required a tracheostomy to bypass. Biopsy findings revealed the mass to be an inflammatory pseudomass secondary to cytomegalovirus (CMV).
View Article and Find Full Text PDFPhenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
J Allergy Clin Immunol
December 2018
Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital, University College London, London, United Kingdom. Electronic address:
Background: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a negative immune regulator. Heterozygous CTLA4 germline mutations can cause a complex immune dysregulation syndrome in human subjects.
Objective: We sought to characterize the penetrance, clinical features, and best treatment options in 133 CTLA4 mutation carriers.
Cytomegalovirus-associated pseudotumor simulating gastric malignancy in acquired immunodeficiency syndrome: a case report with review of literature.
Jpn J Infect Dis
May 2007
Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
We present a case of cytomegalovirus (CMV)-induced pseudotumor of the gastric antrum. Although affliction of the entire gastrointestinal tract with CMV has been described, localization to the stomach and especially the gastric antrum is rare. Kaposi's sarcoma and non-Hodgkin's lymphoma are recognized causes of bowel thickening and obstruction in patients with AIDS, but CMV is an extremely rare cause, with only four cases of CMV-induced pseudotumor reported in the English literature.
View Article and Find Full Text PDFA cytomegalovirus-associated mass presenting with laryngeal obstruction.
Arch Otolaryngol Head Neck Surg
December 2006
Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Cytomegalovirus-associated discrete gastrointestinal masses in macaques infected with the simian immunodeficiency virus.
Vet Pathol
November 2004
New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA.
Cytomegalovirus (CMV)-associated gastrointestinal masses have been reported in human acquired immune deficiency syndrome patients. This is the first report on CMV-associated gastrointestinal masses in simian immunodeficiency virus (SIV)-infected macaques. Two SIV-infected macaques presented at necropsy with multiple nodular or umbilicated masses within the gastrointestinal tract.
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