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Non-random, individual-specific methylation profiles are present at the sixth CTCF binding site in the human H19/IGF2 imprinting control region.
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Laboratoire d'Epigénétique, Centre National de Génotypage, 2 rue Gaston Crémieux, 91000 Evry, France.
Expression of imprinted genes is classically associated with differential methylation of specific CpG-rich DNA regions (DMRs). The H19/IGF2 locus is considered a paradigm for epigenetic regulation. In mice, as in humans, the essential H19 DMR--target of the CTCF insulator--is located between the two genes.
View Article and Find Full Text PDFStandardbred stallion gene transmission for twelve protein systems: evidence for selection in trotters.
Anim Genet
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Department of Psychiatry, University of Rochester Medical Center, New York 14642.
The transmission ratios of alleles at 12 protein marker loci were computed individually for American Standardbred stallions in a genealogy of 5392 phenotyped horses. Over all loci there was significant gene transmission distortion for trotting stallions (p = 0.0019) but not for pacing stallions (p = 0.
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