We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.
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| http://dx.doi.org/10.1016/j.bmcl.2006.11.092 | DOI Listing |
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