Extended-release epidural morphine (DepoDur): an old drug with a new profile.

The FDA has recently approved a novel formulation for epidural morphine administration that allows a single injection to provide 48 hours of analgesia. This may eliminate the need for an indwelling epidural catheter in some circumstances and therefore be particularly well suited to postoperative situations where anticoagulation is required. Other uses that have been less thoroughly studied should be approached with due caution.